{ "schema_version": "1.0.0", "updated": "2026-10-07", "records": [ { "report_id": "RPT-TEMPUS", "provider_id": "tempus", "title": "Tempus xT, xR, DPYD and UGT1A1 reports", "description": "Complete 17-page packet: 648-gene DNA panel, RNA analysis, HLA typing and pharmacogenetics.", "sample_ids": [ "M-SAMPLE-002", "M-SAMPLE-004" ], "assay_ids": [ "M-ASSAY-003", "M-ASSAY-004" ], "assay_id": null, "collection_date": "2024-10-22", "report_date": "2025-02-21", "evidence_class": "clinical_laboratory_report", "provenance_summary": "Rectal resection collected 22 October 2024; matched-normal blood, 28 January 2025. Summary and RNA report dated 21 February 2025; DNA and pharmacogenetic reports, 15 February 2025.", "filename": "tempus.pdf", "path": "reports/tempus/tempus.pdf", "url": "reports/tempus/tempus.pdf", "format": "PDF", "bytes": 11667616, "sha256": "2a2ed5134556869a7258d1d3181926ae4449cf481f3e7195286d5abf3f99d454", "pages": 17, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Tempus", "specimens": [ { "sample_id": "M-SAMPLE-002", "label": "Rectal resection specimen", "anatomical_site": "rectum", "role": "primary_tumour_resection", "collection_date": "2024-10-22", "provenance_status": "primary_Tempus_and_BostonGene_reports_confirmed" }, { "sample_id": "M-SAMPLE-004", "label": "Tempus matched-normal blood", "anatomical_site": "blood", "role": "matched_normal", "collection_date": "2025-01-28", "provenance_status": "primary_Tempus_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "DNA and RNA molecular profiling", "result_summary": { "findings": [ "Rectal resection: APC p.V450fs loss-of-function frameshift at 8.6% variant allele fraction; no reported pathogenic KRAS, NRAS or BRAF variant or copy-number change.", "Microsatellite stable; low tumour mutational burden, 4.2 mutations/Mb. No reportable RNA rearrangement or altered splicing.", "HLA-A A*02:01 / A*02:01; HLA-B B*07:02 / B*44:02; HLA-C C*03:04 / C*05:01.", "No potential germline variant reported within the limited gene set. Somatic variants of unknown significance included CCDC6, ELF3, SMARCA4 and SOX9.", "DPYD: none of five targeted variants detected. UGT1A1 *1/*28: predicted intermediate metabolizer; insufficient evidence for a dose change based on this genotype alone." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 3, 9, 12, 14 ], "note": "Results concern historical rectal resection and matched-normal blood. Limited germline analysis does not exclude hereditary cancer risk." } }, { "report_id": "RPT-CARIS", "provider_id": "caris", "title": "Caris molecular profiling of the initial rectal biopsy", "description": "Complete 23-page report: molecular findings, expression, methods and specimen limitations.", "sample_ids": [ "M-SAMPLE-001" ], "assay_ids": [ "M-ASSAY-001", "M-ASSAY-002" ], "assay_id": null, "collection_date": "2024-03-27", "report_date": "2026-06-03", "evidence_class": "clinical_laboratory_report", "provenance_summary": "Rectal FFPE biopsy collected 27 March 2024.", "filename": "caris.pdf", "path": "reports/caris/caris.pdf", "url": "reports/caris/caris.pdf", "format": "PDF", "bytes": 11123915, "sha256": "1c140de612bc6a5342d482920a1b98152e02aa482b782febc58785f63c1b2294", "pages": 23, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Caris", "specimens": [ { "sample_id": "M-SAMPLE-001", "label": "Initial rectal primary biopsy", "anatomical_site": "rectum", "role": "primary_tumour", "collection_date": "2024-03-27", "provenance_status": "primary_Caris_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "DNA and RNA molecular profiling", "result_summary": { "findings": [ "KRAS, NRAS and BRAF mutations not detected; microsatellite stable; low tumour mutational burden, 5 mutations/Mb.", "Pathogenic APC p.S1411fs and p.V450fs, PTEN p.R335* and SOX9 c.432-2A>T; likely pathogenic SMARCA4 p.D1177Y.", "ERBB2/HER2 and EGFR amplification and NTRK1/2/3, BRAF and RET fusions not detected. Low genomic loss of heterozygosity, 5%.", "Predicted HLA-A A*02:01 / A*02:01; HLA-B B*07:02 / B*44:02; HLA-C C*03:04 / C*05:01. HLA-A loss of heterozygosity not detected.", "FOLFIRSTai reported increased relative benefit for first-line FOLFOX plus bevacizumab in metastatic colorectal cancer." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 3, 5 ], "note": "The superficial biopsy was predominantly intramucosal carcinoma and may not represent invasive or metastatic disease. FOLFIRSTai is a signature result, not evidence I received bevacizumab." } }, { "report_id": "RPT-VALIUS", "provider_id": "valius", "title": "Valius cell surface target report", "description": "Complete 33-page report: single-cell expression, target staining and therapeutic hypotheses.", "sample_ids": [ "M-SAMPLE-003" ], "assay_ids": [ "M-ASSAY-010", "M-ASSAY-011" ], "assay_id": null, "collection_date": "2024-10-22", "report_date": "2026-09", "evidence_class": "investigational_integrated_report", "provenance_summary": "Liver FFPE tissue collected 22 October 2024; 10x Genomics Flex v2. Exact single-cell aliquot-to-block linkage not supplied.", "filename": "valius.pdf", "path": "reports/valius/valius.pdf", "url": "reports/valius/valius.pdf", "format": "PDF", "bytes": 16163202, "sha256": "5ebf6a01720ef9c7ccdd50c50cfaf02b7ccd57a268f3e68496489d3dfe4f3ec3", "pages": 33, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Integrated cell-surface target analysis", "result_summary": { "findings": [ "Archived liver single-cell analysis: 92,897 cells, including 1,018 classified as tumour cells.", "Single-cell expression: MET 41%, CEACAM5 40%, TROP-2 55%, EPCAM 68% and EPHA2 71% of tumour cells.", "Protein staining: CEACAM5 H-score 300, 100% strong; MET H-score 160, 60% moderate and 40% weak cytoplasmic; TROP-2 H-score 20, 10% moderate membranous.", "HER2 protein staining negative despite RNA expression in some tumour cells. MET and CEACAM5 prioritized as therapeutic research hypotheses." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 4, 5, 9, 11, 13, 15, 20, 33 ], "note": "October 2024 liver tissue. Whole-exome and whole-transcriptome sequencing had failed quality control at the time; single-cell profiling and therapeutic hypotheses are investigational." } }, { "report_id": "RPT-TRUFFLEPIG", "provider_id": "trufflepig", "title": "TrufflePig exploratory expression analysis", "description": "30-page research analysis: sample composition, expression, candidate targets and reference-tissue expression.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": null, "evidence_class": "exploratory_research_report", "provenance_summary": "Exploratory analysis; exact specimen, processing date and input manifest absent from the supplied PDF.", "filename": "trufflepig.pdf", "path": "reports/trufflepig/trufflepig.pdf", "url": "reports/trufflepig/trufflepig.pdf", "format": "PDF", "bytes": 14188029, "sha256": "0152aa30e797ceb696387b150ba02abd52018bfb900a715ccd15bdba76cff30e", "pages": 30, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "TrufflePig", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "RNA expression analysis", "result_summary": { "findings": [ "Expression classification most strongly supported rectal adenocarcinoma (READ). Estimated composition: 45% tumour, 30% stroma, 25% immune cells; tumour-purity estimates ranged from 26% to 71%.", "Stromal and immune signals enriched 8.29-fold and 1.43-fold, respectively, versus TCGA READ.", "Hypoxia-associated expression 3.21 times the cohort median; interferon response nearer baseline at 1.39-fold.", "Research targets included CEACAM5, CD46, IGF1R, FGFR2 and EGFR, compared with colorectal cancer and healthy-tissue expression references." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 6, 7, 9, 10, 30 ], "note": "Bulk-RNA model estimates, not measured tumour-cell counts or confirmed protein targets. Source specimen and inputs remain unverified." } }, { "report_id": "RPT-CLINICAL-SEPTEMBER-PET", "provider_id": "clinical", "title": "September 2026 FDG PET/CT report", "description": "Two-page signed report: nodal progression above and below the diaphragm.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2026-09-28", "evidence_class": "clinical_imaging_report", "provenance_summary": "Study and sign-out 28 September 2026. Original wording and historical indication dates retained without correction.", "filename": "clinical_september_pet.pdf", "path": "reports/clinical/clinical_september_pet.pdf", "url": "reports/clinical/clinical_september_pet.pdf", "format": "PDF", "bytes": 1060447, "sha256": "30dc4e1bc2378064b9625091f8ecf7782848b439b46e3ec36d40e5d2396c9fdd", "pages": 2, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · PET/CT", "result_summary": { "findings": [ "Metabolically active nodal progression above and below the diaphragm: new supraclavicular, posterior mediastinal and retrocrural nodes; recurrent/more numerous retroperitoneal nodes.", "Examples: left supraclavicular cluster 14 mm, SUVmax 3.2; aortocaval cluster 14 mm, SUVmax 8.2; left para-aortic cluster 13 mm, SUVmax 7.9.", "No suspicious liver lesion or focal suspicious bone lesion described. Nonspecific small subpleural lung nodules; monitoring recommended.", "Left supraclavicular nodes accessible for ultrasound-guided biopsy." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ] } }, { "report_id": "RPT-CLINICAL-APRIL-PET", "provider_id": "clinical", "title": "April 2026 FDG PET/CT report", "description": "Four-page portal report with imaging measurements and impression.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2026-04-08", "evidence_class": "clinical_imaging_report", "provenance_summary": "Study 8 April 2026. Portal navigation links removed; findings and acquisition details retained.", "filename": "clinical_april_pet.pdf", "path": "reports/clinical/clinical_april_pet.pdf", "url": "reports/clinical/clinical_april_pet.pdf", "format": "PDF", "bytes": 1718349, "sha256": "5298041a387ccf620786a972590fe7fcd89133f7d080008a9765a443e8c948be", "pages": 4, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · PET/CT", "result_summary": { "findings": [ "New FDG-avid periaortic nodes concerning for metastases: right para-aortic 7 × 15 mm, SUVmax 4.3; left para-aortic 8 × 12 mm, SUVmax 3.6.", "Periportal/periceliac soft tissue remained about 16 mm, with a small uptake increase to SUVmax 2.1.", "Postoperative rectal changes without definite FDG-avid local recurrence." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 2, 3 ] } }, { "report_id": "RPT-CLINICAL-HER2-PATHOLOGY", "provider_id": "clinical", "title": "Liver HER2 add-on and original resection pathology", "description": "Six-page packet: HER2 staining, rectal/liver resection pathology, stage and margins.", "sample_ids": [ "M-SAMPLE-002", "M-SAMPLE-003" ], "assay_ids": [], "assay_id": null, "collection_date": "2024-10-22", "report_date": "2026-04-29", "evidence_class": "clinical_pathology_report", "provenance_summary": "HER2 add-on reported 29 April 2026 on archived liver tissue. Includes pathology from 22 October 2024 surgery, signed 28 October 2024.", "filename": "clinical_her2_pathology.pdf", "path": "reports/clinical/clinical_her2_pathology.pdf", "url": "reports/clinical/clinical_her2_pathology.pdf", "format": "PDF", "bytes": 3031015, "sha256": "8ded3cfa7c3e159a792c178c875a9b1dfec4d3cfc90e637a5ff2ed29f5378349", "pages": 6, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [ { "sample_id": "M-SAMPLE-002", "label": "Rectal resection specimen", "anatomical_site": "rectum", "role": "primary_tumour_resection", "collection_date": "2024-10-22", "provenance_status": "primary_Tempus_and_BostonGene_reports_confirmed" }, { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Immunohistochemistry", "result_summary": { "findings": [ "Archived liver HER2: IHC 0, negative by HERACLES criteria.", "Rectal resection: residual moderately differentiated adenocarcinoma with treatment-associated mucinous features; partial treatment response, score 2.", "Pathologic stage ypT3N1aM1a; 1 of 12 regional nodes positive, numerous tumour deposits, extramural venous and perineural invasion.", "Negative rectal and liver margins; closest rectal circumferential margin 2 mm. Liver resection confirmed metastatic colorectal adenocarcinoma." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 3, 4, 6 ], "note": "The April 2026 HER2 add-on used October 2024 tissue; reaccession was not a new collection." } }, { "report_id": "RPT-CLINICAL-INITIAL-BIOPSY", "provider_id": "clinical", "title": "Initial rectosigmoid biopsy pathology", "description": "Two-page biopsy report: MMR immunohistochemistry and sampling limitations.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": "2024-03-18", "report_date": "2024-03-21", "evidence_class": "clinical_pathology_report", "provenance_summary": "Collected 18 March 2024; histology signed 20 March; MMR addendum 21 March 2024.", "filename": "clinical_initial_biopsy.pdf", "path": "reports/clinical/clinical_initial_biopsy.pdf", "url": "reports/clinical/clinical_initial_biopsy.pdf", "format": "PDF", "bytes": 925121, "sha256": "23817d365d974353a5c229ae662f13dd1116f9bf987b5d420e0135d6cbdec6d8", "pages": 2, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Histology and slide reviews", "result_summary": { "findings": [ "At least high-grade dysplasia in a tubulovillous adenoma; suspicious for invasive adenocarcinoma.", "MLH1, MSH2, MSH6 and PMS2 nuclear expression retained; no mismatch-repair protein loss." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "The superficial biopsy could not establish definite invasion; the report cautions against overinterpreting MMR in this sampling context." } }, { "report_id": "RPT-CLINICAL-REPEAT-BIOPSY", "provider_id": "clinical", "title": "Repeat rectal biopsy pathology", "description": "Two-page report: moderately differentiated adenocarcinoma and intact MMR proteins.", "sample_ids": [ "M-SAMPLE-001" ], "assay_ids": [], "assay_id": null, "collection_date": "2024-03-27", "report_date": "2024-03-29", "evidence_class": "clinical_pathology_report", "provenance_summary": "Collected 27 March 2024; signed 29 March 2024. Corresponds to the initial-primary material profiled by Caris.", "filename": "clinical_repeat_biopsy.pdf", "path": "reports/clinical/clinical_repeat_biopsy.pdf", "url": "reports/clinical/clinical_repeat_biopsy.pdf", "format": "PDF", "bytes": 747677, "sha256": "201e8ec7bc7be1156dc48945d465c8f78d90c2d84ae6193444bc0013ce12043e", "pages": 2, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [ { "sample_id": "M-SAMPLE-001", "label": "Initial rectal primary biopsy", "anatomical_site": "rectum", "role": "primary_tumour", "collection_date": "2024-03-27", "provenance_status": "primary_Caris_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Histology and slide reviews", "result_summary": { "findings": [ "Repeat rectal biopsy confirmed moderately differentiated adenocarcinoma arising in a tubulovillous adenoma with high-grade dysplasia.", "MLH1, MSH2, MSH6 and PMS2 nuclear expression retained; no mismatch-repair protein loss." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ] } }, { "report_id": "RPT-CLINICAL-BASELINE-CT-CHEST", "provider_id": "clinical", "title": "Baseline CT chest report", "description": "March 2024 CT chest findings and acquisition details.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2024-03-20", "evidence_class": "clinical_imaging_report", "provenance_summary": "Study/report 20 March 2024; three-page portal print.", "filename": "clinical_baseline_ct_chest.pdf", "path": "reports/clinical/clinical_baseline_ct_chest.pdf", "url": "reports/clinical/clinical_baseline_ct_chest.pdf", "format": "PDF", "bytes": 745698, "sha256": "875ed68dfe6735332fb60327b2e196412eed43c3beca3b21a449f95f2821c083", "pages": 3, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · CT", "result_summary": { "findings": [ "No definite intrathoracic metastatic disease or thoracic lymphadenopathy.", "Left-upper-lobe micronodule, 1 mm: most likely a mucus plug, not a definite metastasis." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ] } }, { "report_id": "RPT-CLINICAL-BASELINE-CT-ABDOMEN", "provider_id": "clinical", "title": "Baseline CT abdomen and pelvis report", "description": "March 2024 CT: rectal mass and indeterminate liver lesions.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2024-03-20", "evidence_class": "clinical_imaging_report", "provenance_summary": "Study/report 20 March 2024; three-page portal print.", "filename": "clinical_baseline_ct_abdomen.pdf", "path": "reports/clinical/clinical_baseline_ct_abdomen.pdf", "url": "reports/clinical/clinical_baseline_ct_abdomen.pdf", "format": "PDF", "bytes": 818180, "sha256": "4c7d8b00e6b605c44bf2fbfa6e5979d364c8cc1e83c7d6bfdf5f5302cf267bcb", "pages": 3, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · CT", "result_summary": { "findings": [ "Proximal rectal mass approximately 5.9 × 3.5 × 5 cm; adjacent 2.2 cm pelvic nodule could be part of the mass or a node.", "Indeterminate liver lesions, including a 23 × 20 mm left-lobe lesion not clearly a cyst.", "Hepatic and pelvic MRI recommended to clarify liver lesions and pelvic nodal involvement." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ] } }, { "report_id": "RPT-CLINICAL-BASELINE-MRI-PELVIS", "provider_id": "clinical", "title": "Baseline MRI pelvis report", "description": "March 2024 rectal MRI: stage, nodes and margins.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2024-03-25", "evidence_class": "clinical_imaging_report", "provenance_summary": "Study/signed report 25 March 2024; three-page portal print.", "filename": "clinical_baseline_mri_pelvis.pdf", "path": "reports/clinical/clinical_baseline_mri_pelvis.pdf", "url": "reports/clinical/clinical_baseline_mri_pelvis.pdf", "format": "PDF", "bytes": 1077982, "sha256": "11c3a4b9ce35a8b51e78986b1e4e7c0e025ee7839e6642662156ddbdc1b2e0a1", "pages": 3, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · MRI", "result_summary": { "findings": [ "Upper rectal tumour approximately 5.5 cm long; MRI stage T3dN2Mx; extramural invasion 26 mm.", "Circumferential resection margin involved; sphincter uninvolved. Extramural venous invasion/tumour deposits and suspicious regional nodes described.", "Possible invasion into an adjacent sigmoid loop remained uncertain; abutment/scan technique could explain the appearance." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ] } }, { "report_id": "RPT-CLINICAL-BASELINE-MRI-LIVER", "provider_id": "clinical", "title": "Baseline MRI abdomen report", "description": "March 2024 MRI: suspected hepatic metastasis.", "sample_ids": [], "assay_ids": [], "assay_id": null, "collection_date": null, "report_date": "2024-03-27", "evidence_class": "clinical_imaging_report", "provenance_summary": "Signed 27 March 2024; ordered 26 March. Acquisition date unverified.", "filename": "clinical_baseline_mri_liver.pdf", "path": "reports/clinical/clinical_baseline_mri_liver.pdf", "url": "reports/clinical/clinical_baseline_mri_liver.pdf", "format": "PDF", "bytes": 788987, "sha256": "9b273eb57a841b59eda50fdb4e30b31dcf87ceede971401202ec800d0560ed31", "pages": 3, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Clinical records & imaging", "specimens": [], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Imaging · MRI", "result_summary": { "findings": [ "Left hepatic lesion, 23 × 22 mm, with restricted diffusion: highly concerning for metastasis.", "Additional subcentimetre right-lobe focus too small to characterize.", "Itching and hives documented after Eovist contrast." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "Source discrepancy retained: the main lesion is labelled segment 3 in the body and segment 2 in the impression." } }, { "report_id": "RPT-NATERA-SIGNATERA", "provider_id": "natera", "title": "Natera Signatera report and historical ctDNA results", "description": "Two-page report: positive 1.69 MTM/mL on 16 June 2026, 12 historical results and full assay limitations.", "sample_ids": [ "M-SAMPLE-010", "M-SAMPLE-012" ], "assay_ids": [ "M-ASSAY-018" ], "assay_id": "M-ASSAY-018", "collection_date": "2026-06-16", "report_date": "2026-06-23", "evidence_class": "clinical_laboratory_report", "provenance_summary": "Plasma collected 16 June 2026. Assay-design tissue: rectal resection section collected 22 October 2024, distinct from liver material. Exact sequencing BAM IDs absent from the report.", "filename": "natera_signatera.pdf", "path": "reports/natera/natera_signatera.pdf", "url": "reports/natera/natera_signatera.pdf", "format": "PDF", "bytes": 1118832, "sha256": "9eeedd3169e12e330afdbc723ab21dedd606388b30e4dabba9ac6e7fc612a640", "pages": 2, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Natera", "specimens": [ { "sample_id": "M-SAMPLE-010", "label": "Rectal resection block B7 — Natera assay design", "anatomical_site": "rectum", "role": "primary_tumour_resection", "collection_date": "2024-10-22", "provenance_status": "primary_Signatera_report_confirmed" }, { "sample_id": "M-SAMPLE-012", "label": "Natera Signatera plasma — 16 June 2026", "anatomical_site": "blood_plasma", "role": "ctDNA_monitoring", "collection_date": "2026-06-16", "provenance_status": "primary_Signatera_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Liquid biopsy · ctDNA and plasma profiling", "result_summary": { "findings": [ "16 June 2026 plasma: ctDNA positive, 1.69 mean tumour molecules/mL (MTM/mL).", "Historical values: 68.63 MTM/mL on 31 March 2026, 13.31 on 17 March, 0.00 on 27 January; 12 dated draws listed.", "A full panel of 16 bespoke assays could not be designed from the tumour section, potentially reducing sensitivity." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "Tumour-informed monitoring, not broad resistance genotyping. Negative results do not exclude cancer; single MTM/mL values should not be compared across patients." } }, { "report_id": "RPT-VALIUS-PORTRAIT", "provider_id": "valius", "title": "BostonGene Tumor Portrait through Valius", "description": "25-page genomic/transcriptomic profile with tumour microenvironment analysis and methods.", "sample_ids": [ "M-SAMPLE-002", "M-SAMPLE-011" ], "assay_ids": [ "M-ASSAY-019" ], "assay_id": "M-ASSAY-019", "collection_date": "2024-10-22", "report_date": "2026-09-30", "evidence_class": "clinical_laboratory_report", "provenance_summary": "BostonGene: rectal FFPE resection collected 22 October 2024; saliva normal, 13 May 2026. Distinct from liver tissue used for Valius single-cell/IHC reports.", "filename": "valius_portrait.pdf", "path": "reports/valius/valius_portrait.pdf", "url": "reports/valius/valius_portrait.pdf", "format": "PDF", "bytes": 9117417, "sha256": "a996b19275f3d264d4c2de9fc8c5f026daad5cc7e9bdec75889dcb45ed753a69", "pages": 25, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-002", "label": "Rectal resection specimen", "anatomical_site": "rectum", "role": "primary_tumour_resection", "collection_date": "2024-10-22", "provenance_status": "primary_Tempus_and_BostonGene_reports_confirmed" }, { "sample_id": "M-SAMPLE-011", "label": "BostonGene matched-normal saliva", "anatomical_site": "saliva", "role": "matched_normal", "collection_date": "2026-05-13", "provenance_status": "primary_BostonGene_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "DNA and RNA molecular profiling", "result_summary": { "findings": [ "October 2024 rectal resection: estimated tumour content 15%; tumour mutational burden 0.42 mutations/Mb. Copy-number alterations and MSI unreported because tumour content was low.", "No oncogenic NTRK1/2/3 or RET fusion or pathogenic/likely pathogenic germline variant in the limited reportable set. No biomarker-based treatment option suggested.", "RNA microenvironment classification: fibrotic, immune non-inflamed; low MHC-I and medium PD-L1 expression signatures; enriched fibroblasts and endothelial cells.", "HLA-A*02:01 identified for trial matching; confirmation of predicted HLA typing recommended." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 3, 4 ], "note": "Residual rectal tumour after chemoradiation, with 15% tumour content. Low purity limits mutation detection and interpretation of TMB. Bulk-RNA microenvironment signatures include stromal and immune cells and do not establish tumour-cell MHC-I loss or the immune state of current metastases. Historical external HER2/MMR entries are not new tests of this specimen." } }, { "report_id": "RPT-VALIUS-CEA", "provider_id": "valius", "title": "Valius / Peninsula Pathologists CEA staining", "description": "CEA IHC: H-score 300; 100% strong cytoplasmic/membranous tumour staining.", "sample_ids": [ "M-SAMPLE-003" ], "assay_ids": [ "M-ASSAY-011" ], "assay_id": "M-ASSAY-011", "collection_date": "2024-10-22", "report_date": null, "evidence_class": "clinical_pathology_report", "provenance_summary": "Liver left lateral segment FFPE; estimated viable tumour 5%. Collected 22 October 2024 per resection pathology; reaccessioned 28 April 2026. Issue date absent.", "filename": "valius_cea.pdf", "path": "reports/valius/valius_cea.pdf", "url": "reports/valius/valius_cea.pdf", "format": "PDF", "bytes": 358820, "sha256": "7001fae74f8d12fe0b4e325a120b857d823076ee851204dc17e5342ea16ac36e", "pages": 1, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Immunohistochemistry", "result_summary": { "findings": [ "CEA/CEACAM5 tumour H-score 300: 100% strong (3+) cytoplasmic and membranous staining.", "Stroma negative. Archived liver block C4 adequate for IHC; approximately 5% viable tumour in a predominantly acellular mucinous lesion." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1 ] } }, { "report_id": "RPT-VALIUS-HER2", "provider_id": "valius", "title": "Valius / Peninsula Pathologists HER2 staining", "description": "HER2 IHC 0, H-score 0; assay and scoring details.", "sample_ids": [ "M-SAMPLE-003" ], "assay_ids": [ "M-ASSAY-011" ], "assay_id": "M-ASSAY-011", "collection_date": "2024-10-22", "report_date": null, "evidence_class": "clinical_pathology_report", "provenance_summary": "Liver left lateral segment FFPE; estimated viable tumour 5%. Collected 22 October 2024; 28 April 2026 is the reaccession date, not new surgery.", "filename": "valius_her2.pdf", "path": "reports/valius/valius_her2.pdf", "url": "reports/valius/valius_her2.pdf", "format": "PDF", "bytes": 370861, "sha256": "3ee6fb9d910dec3e7eb5d6686f9ae7bcdb651b9fb6f1791fc10800b481453c8e", "pages": 1, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Immunohistochemistry", "result_summary": { "findings": [ "HER2 IHC 0, tumour H-score 0: no tumour or stromal staining; negative by colorectal HERACLES criteria.", "Archived liver block C4: approximately 5% viable tumour; pathologist considered it adequate for IHC." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1 ] } }, { "report_id": "RPT-VALIUS-TROP2", "provider_id": "valius", "title": "Valius / Peninsula Pathologists TROP-2 staining", "description": "TROP-2 H-score 20; moderate membranous staining in 10% of tumour cells.", "sample_ids": [ "M-SAMPLE-003" ], "assay_ids": [ "M-ASSAY-011" ], "assay_id": "M-ASSAY-011", "collection_date": "2024-10-22", "report_date": null, "evidence_class": "clinical_pathology_report", "provenance_summary": "Liver left lateral segment FFPE; estimated viable tumour 5%. Collected 22 October 2024; reaccessioned 28 April 2026.", "filename": "valius_trop2.pdf", "path": "reports/valius/valius_trop2.pdf", "url": "reports/valius/valius_trop2.pdf", "format": "PDF", "bytes": 434709, "sha256": "2ab3cc6872ca6c87a87606d89cdee2e47c148363ba8d7f3a28bc6000d63bce22", "pages": 1, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Immunohistochemistry", "result_summary": { "findings": [ "TROP-2 tumour H-score 20: 10% moderate (2+) membranous staining; 90% negative.", "Weak cytoplasmic staining in about 10% excluded from scoring. Stroma negative." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1 ], "note": "The report states that TROP-2 staining has no established relationship with treatment response in colorectal cancer. Archived liver tissue, not a current-node assay." } }, { "report_id": "RPT-VALIUS-MET", "provider_id": "valius", "title": "Valius / Peninsula Pathologists cMET staining", "description": "cMET H-score 160; 60% 2+, 40% 1+, 0% 3+; cytoplasmic tumour staining.", "sample_ids": [ "M-SAMPLE-003" ], "assay_ids": [ "M-ASSAY-011" ], "assay_id": "M-ASSAY-011", "collection_date": "2024-10-22", "report_date": null, "evidence_class": "clinical_pathology_report", "provenance_summary": "Liver left lateral segment FFPE; estimated viable tumour 5%. Collected 22 October 2024; reaccessioned 28 April 2026. Staining location/intensity retained as reported.", "filename": "valius_met.pdf", "path": "reports/valius/valius_met.pdf", "url": "reports/valius/valius_met.pdf", "format": "PDF", "bytes": 406452, "sha256": "731d07eb65a04c770533366af8d8b37d459d5e9b64312a854968260554f17048", "pages": 1, "preparation": "Rasterized public copy. Identifying administrative fields removed; scientific pages, figures and vendor attribution retained. Original hidden text, links, metadata and attachments omitted.", "provider": "Valius / Kandinsky / BostonGene", "specimens": [ { "sample_id": "M-SAMPLE-003", "label": "Liver metastasis resection specimen", "anatomical_site": "liver", "role": "metastasis", "collection_date": "2024-10-22", "provenance_status": "previous_report_review" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Pathology · Immunohistochemistry", "result_summary": { "findings": [ "cMET tumour H-score 160: 60% moderate (2+), 40% weak (1+), no strong (3+) staining.", "Cytoplasmic staining; stroma negative. Archived liver block C4: about 5% viable tumour; adequate for IHC." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1 ], "note": "The report cautions that IHC does not reliably establish MET exon-14 alteration or amplification." } }, { "report_id": "RPT-INVOKE", "provider_id": "invoke", "title": "Invoke Bio / Aureon multi-sample vaccine target report", "description": "Interactive research report: candidate rankings, sequences, expression and immunogenicity figures. All 250 embedded IGV sessions omitted; cells labelled “Snapshot omitted”.", "sample_ids": [ "M-SAMPLE-001", "M-SAMPLE-008" ], "assay_ids": [ "M-ASSAY-012", "M-ASSAY-013", "M-ASSAY-014", "M-ASSAY-017" ], "collection_date": null, "report_date": "2026-09-28", "evidence_class": "Research vaccine-design report", "provenance_summary": "Earlier read audits support selected primary-biopsy input linkage. Complete input manifest and normal-sample identity remain unresolved.", "filename": "aureon_vaccine_target_report.html", "path": "reports/invoke/aureon_vaccine_target_report.html", "format": "HTML", "preparation": "Multi-file HTML preserves scientific tables and figure data; embedded read sessions and fonts omitted. View online, or extract the source ZIP, serve the folder locally, and open reports/invoke/aureon_vaccine_target_report.html with its adjacent files. ZIP excludes PDFs.", "dependencies": [ "reports/invoke/plotly.min.js", "reports/invoke/report.js", "reports/invoke/figure_data.json", "reports/invoke/plotly-license.txt" ], "bytes": 873590, "sha256": "ac3d15929223f4525bc88ca2333b6eb3e6cdabc1461425766fe7c9067ffacd8e", "url": "reports/invoke/aureon_vaccine_target_report.html", "view_url": "reports/invoke/aureon_vaccine_target_report.html", "bundle_download_url": "downloads/source.zip", "provider": "Invoke Bio / Aureon", "specimens": [ { "sample_id": "M-SAMPLE-001", "label": "Initial rectal primary biopsy", "anatomical_site": "rectum", "role": "primary_tumour", "collection_date": "2024-03-27", "provenance_status": "primary_Caris_report_confirmed" }, { "sample_id": "M-SAMPLE-008", "label": "Normal material used in Invoke embedded tracks", "anatomical_site": "not_confirmed", "role": "normal_label_in_research_report", "collection_date": null, "provenance_status": "provider_confirmation_requested" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Vaccine designs", "result_summary": { "findings": [ "Tier-ranked multi-sample neoantigen candidates with DNA/RNA allele fractions, expression, proposed 25-mer sequences and predicted CD8/CD4 epitopes.", "Leading candidates include STAG3 p.D893Y, KLHL26 p.V126M and PRKDC stop-loss; epitope tables list HLA restrictions and candidate probabilities.", "CD8/CD4 probabilities and immunogenicity figures are model predictions, not measured immune recognition." ], "basis": "Report summary; no cross-provider interpretation.", "note": "Historical research design with unresolved input mapping; candidates do not establish current-node retention, antigen presentation or a final manufactured vaccine. Public copy omits alignment snapshots.", "section": "Integrated candidate and epitope tables; expression and immunogenicity figures" } }, { "report_id": "RPT-JLF", "provider_id": "jlf", "title": "JLF peptide candidate list", "description": "20 precursor candidates, HLA restrictions and source notes. HTML preserves red class-I epitopes, bold class-II epitopes, underlined variant residues and green driver-gene fills.", "sample_ids": [ "M-SAMPLE-001" ], "assay_ids": [ "M-ASSAY-016" ], "collection_date": null, "report_date": null, "evidence_class": "Research peptide-design workbook rendering", "provenance_summary": "Undated, patient-supplied design workbook based on historical tumour sequencing.", "filename": "peptide_candidate_list.html", "path": "reports/jlf/peptide_candidate_list.html", "format": "HTML", "preparation": "All 130 populated cells and 1,086 text-format runs checked against the workbook. Styling and fills preserve scientific annotations; CSV retains plain values only. Workbook metadata and editing history omitted.", "dependencies": [ "reports/jlf/peptide_candidate_list.csv" ], "table_download_url": "reports/jlf/peptide_candidate_list.csv", "bytes": 138209, "sha256": "4d25c1f4af99a96883aab94c254beee1d519f9f3e55595dafaf7201d2ac6651a", "url": "reports/jlf/peptide_candidate_list.html", "view_url": "reports/jlf/peptide_candidate_list.html", "bundle_download_url": "downloads/source.zip", "provider": "JLF", "specimens": [ { "sample_id": "M-SAMPLE-001", "label": "Initial rectal primary biopsy", "anatomical_site": "rectum", "role": "primary_tumour", "collection_date": "2024-03-27", "provenance_status": "primary_Caris_report_confirmed" } ], "license_status": "third_party_report_or_design_rights_retained", "browse_type": "Vaccine designs", "result_summary": { "findings": [ "20 proposed peptide precursors with flanking amino-acid sequences and HLA restrictions.", "Candidates include APC, SMAD4, CCDC6, SMARCA4 and ELF3. Online tables retain class-I/class-II epitope and variant-residue annotations.", "Class-I restrictions include A*02:01, B*07:02, B*44:02, C*03:04 and C*05:01. Some rows specify class-II DPA1*01:03-DPB1*02:01 or DQA1*01:02-DQB1*06:02." ], "basis": "Report summary; no cross-provider interpretation.", "note": "Historical, undated candidate design; does not identify final manufactured peptides or confirm vaccination.", "section": "Candidate table and source notes" } }, { "provider_id": "clinical", "report_id": "RPT-CLINICAL-JUNE-PET", "title": "June 2026 FDG PET/CT report", "collection_date": null, "report_date": "2026-06-11", "study_date": "2026-06-11", "description": "Complete three-page report: response of previously hypermetabolic retroperitoneal nodes.", "provenance_summary": "Study/final signatures 11 June 2026. Original comparison-date inconsistencies and clinical history retained; neither establishes procedure or administration dates.", "path": "reports/clinical/portal_ucla_pet_2026_06_11.pdf", "url": "reports/clinical/portal_ucla_pet_2026_06_11.pdf", "filename": "portal_ucla_pet_2026_06_11.pdf", "format": "PDF", "bytes": 1293469, "sha256": "5d298fa5562f84a4131a71d616cf9e8aa68c25dbb88e1bd243f17210382f563e", "pages": 3, "source_ids": [ "CL-SRC-233" ], "sample_ids": [], "assay_ids": [], "assay_id": null, "evidence_class": "clinical_imaging_report", "preparation": "Rasterized public copy. Identifying administrative fields, contacts and machine-readable identifiers removed; clinical dates, findings, methods, wording and vendor attribution retained. Original text layer, links, metadata and attachments omitted.", "license_status": "third_party_report_or_design_rights_retained", "selected_original_pages": [ 1, 2, 3 ], "provider": "Clinical records & imaging", "specimens": [], "specimen_description": "Whole-body FDG PET/CT study", "browse_type": "Imaging · PET/CT", "result_summary": { "findings": [ "FDG avidity resolved in previously hypermetabolic retroperitoneal nodes; no new lesions or evidence of progression.", "Residual nodes mildly prominent: right para-aortic 8 × 14 mm, SUVmax 1.8; left para-aortic 8 × 12 mm, SUVmax 1.5.", "Periportal/periceliac soft tissue stable in size, with low uptake, SUVmax 1.6." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 2, 3 ], "note": "Comparison dates are inconsistent; no missing comparison measurement is inferred." } }, { "provider_id": "tempus", "report_id": "RPT-TEMPUS-PERSONALIS-AMENDED", "title": "Tempus xM / Personalis amended ctDNA report", "collection_date": "2025-12-18", "report_date": "2026-02-27", "description": "Two amended pages from a five-page packet; blank and superseded pages omitted.", "provenance_summary": "One specimen/result: 245 PPM. Collection corrected from 19 to 18 December 2025. Header/signature dated 27 February 2026; amendment sentence prints 2025-02-27.", "path": "reports/tempus/portal_personalis_amended_2026_02_27.pdf", "url": "reports/tempus/portal_personalis_amended_2026_02_27.pdf", "filename": "portal_personalis_amended_2026_02_27.pdf", "format": "PDF", "bytes": 1019337, "sha256": "61af2e1778884bbd354d4918afdd5b33ae5bb64fc3f1ee322ba5f8a189e68d96", "pages": 2, "source_ids": [ "CL-SRC-241" ], "sample_ids": [], "assay_ids": [], "assay_id": null, "evidence_class": "clinical_laboratory_report", "preparation": "Rasterized public copy. Identifying administrative fields, contacts and machine-readable identifiers removed; clinical dates, findings, methods, wording and vendor attribution retained. Original text layer, links, metadata and attachments omitted.", "license_status": "third_party_report_or_design_rights_retained", "selected_original_pages": [ 1, 2 ], "provider": "Tempus / Personalis", "specimens": [], "specimen_description": "Blood collected 2025-12-18", "browse_type": "Liquid biopsy · ctDNA and plasma profiling", "result_summary": { "findings": [ "Tumour-informed ctDNA detected: 245 parts per million (PPM), plasma collected 18 December 2025.", "Collection date amended from 19 to 18 December; one specimen/result, not a second draw." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "PPM differs from Signatera MTM/mL. The amendment sentence conflicts with the February 2026 header/signature." } }, { "provider_id": "guardant", "report_id": "RPT-GUARDANT360-LIQUID", "title": "Guardant360 Liquid report, December 2025", "collection_date": "2025-12-18", "report_date": "2025-12-24", "description": "Complete seven-page report: somatic, epigenetic and pharmacogenomic findings; methods.", "provenance_summary": "Low-fraction plasma profile: tumour fraction <0.05%, biomarker-negative confidence <90%; blood TMB not evaluable, MSI-High not detected; TRAF2 T113I VUS.", "path": "reports/guardant/portal_guardant_2025_12_24.pdf", "url": "reports/guardant/portal_guardant_2025_12_24.pdf", "filename": "portal_guardant_2025_12_24.pdf", "format": "PDF", "bytes": 4773234, "sha256": "fb1303704cd9bc89b366ba9bbbcce266942ab821d097d0e3b8526e3cd7fff8fb", "pages": 7, "source_ids": [ "CL-SRC-242" ], "sample_ids": [], "assay_ids": [], "assay_id": null, "evidence_class": "clinical_laboratory_report", "preparation": "Rasterized public copy. Identifying administrative fields, contacts and machine-readable identifiers removed; clinical dates, findings, methods, wording and vendor attribution retained. Original text layer, links, metadata and attachments omitted.", "license_status": "third_party_report_or_design_rights_retained", "selected_original_pages": [ 1, 2, 3, 4, 5, 6, 7 ], "provider": "Guardant Health", "specimens": [], "specimen_description": "Blood collected 2025-12-18", "browse_type": "Liquid biopsy · ctDNA and plasma profiling", "result_summary": { "findings": [ "No reportable somatic alteration with an associated therapy; estimated tumour fraction <0.05%, biomarker-negative confidence <90%.", "Blood tumour mutational burden not evaluable; MSI-High not detected. TRAF2 T113I at 1.7%: variant of uncertain significance.", "UGT1A1 *1/*28 and CYP2D6 *1/*4: intermediate-metabolizer genotypes. No abnormal DPYD variant detected among reportable alleles.", "HLA-A A*02:01 / A*02:01; HLA-B B*07:02 / B*44:02; HLA-C C*03:04 / C*05:01." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2, 3 ], "note": "Essentially undetectable tumour DNA (<0.05% estimated tumour fraction) limits negative findings. TRAF2 at 1.7% cfDNA allele fraction is not confirmed tumour-derived; allele fraction and tumour fraction are different measurements. This assay does not establish current tumour genotype or absence of disease." } }, { "provider_id": "caris", "report_id": "RPT-CARIS-ASSURE", "title": "Caris Assure blood report, January 2026", "collection_date": "2026-01-27", "report_date": "2026-02-06", "description": "Complete four-page report and two-page technical appendix.", "provenance_summary": "Blood collected 27 January 2026. Alternate portal copies represent the same specimen.", "path": "reports/caris/portal_caris_assure_2026_02_06.pdf", "url": "reports/caris/portal_caris_assure_2026_02_06.pdf", "filename": "portal_caris_assure_2026_02_06.pdf", "format": "PDF", "bytes": 2366305, "sha256": "4b4ab3b25c654e4f7f69728a5e21090440808c5824a35d07a0f8272738128bdf", "pages": 6, "source_ids": [ "CL-SRC-243" ], "sample_ids": [], "assay_ids": [], "assay_id": null, "evidence_class": "clinical_laboratory_report", "preparation": "Rasterized public copy. Identifying administrative fields, contacts and machine-readable identifiers removed; clinical dates, findings, methods, wording and vendor attribution retained. Original text layer, links, metadata and attachments omitted.", "license_status": "third_party_report_or_design_rights_retained", "selected_original_pages": [ 1, 2, 3, 4, 5, 6 ], "provider": "Caris", "specimens": [], "specimen_description": "Blood collected 2026-01-27", "browse_type": "Liquid biopsy · ctDNA and plasma profiling", "result_summary": { "findings": [ "Estimated tumour fraction 0.0%; no pathogenic tumour-derived somatic variant or therapy-associated biomarker detected.", "Blood tumour mutational burden and microsatellite instability indeterminate—not low TMB or confirmed microsatellite stability.", "No incidental pathogenic germline or clonal-haematopoiesis variant detected within the reportable set. DPYD: no detected variant, activity score 2.0, normal-metabolizer phenotype.", "Predicted HLA-A A*02:01 / A*02:01; HLA-B B*44:02 / B*07:02; HLA-C C*05:01 / C*03:04." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "Low tumour fraction can cause false negatives. Limited incidental germline screening does not exclude hereditary risk." } }, { "provider_id": "clinical", "report_id": "RPT-CLINICAL-CITY-OF-HOPE-PATHOLOGY", "title": "City of Hope review of rectal and liver resection slides", "collection_date": "2024-10-22", "report_date": "2025-11-28", "description": "Complete two-page outside review of four resection slides.", "provenance_summary": "Archived tissue collected 22 October 2024; four slides reviewed 28 November 2025. Several measurements, margins and 1-of-12 node count are from the original report.", "path": "reports/clinical/portal_city_of_hope_pathology_2025_11_28.pdf", "url": "reports/clinical/portal_city_of_hope_pathology_2025_11_28.pdf", "filename": "portal_city_of_hope_pathology_2025_11_28.pdf", "format": "PDF", "bytes": 801522, "sha256": "bfbafe38e61f1c44fc394182197415ab3e219755416063d1d4e246586fea6ae4", "pages": 2, "source_ids": [ "CL-SRC-237" ], "sample_ids": [], "assay_ids": [], "assay_id": null, "evidence_class": "clinical_pathology_review", "preparation": "Rasterized public copy. Identifying administrative fields, contacts and machine-readable identifiers removed; clinical dates, findings, methods, wording and vendor attribution retained. Original text layer, links, metadata and attachments omitted.", "license_status": "third_party_report_or_design_rights_retained", "selected_original_pages": [ 1, 2 ], "provider": "Clinical records & imaging", "specimens": [], "specimen_description": "Archived rectal and liver resection tissue; four submitted slides", "browse_type": "Pathology · Histology and slide reviews", "result_summary": { "findings": [ "Review agreed with residual moderately differentiated colorectal adenocarcinoma with mucinous features invading pericolorectal fat; liver slides showed metastatic adenocarcinoma consistent with colorectal origin.", "Stage ypT3 pN1a pM1a; partial treatment response, score 2; multiple tumour deposits; 1 of 12 regional nodes positive.", "Negative rectal/liver margins and lymphovascular/perineural invasion recorded from the original resection report." ], "basis": "Report summary; no cross-provider interpretation.", "pages": [ 1, 2 ], "note": "Four-slide review of archived tissue; several findings are by report, not a new complete specimen examination." } } ] }